Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress.

  title={Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress.},
  author={Yasuhiro Kanbara and Kazuyoshi Murakane and Yumiko Nishimura and Masaya Satoh and Yasuo Oyama},
  journal={The Journal of toxicological sciences},
  volume={38 1},
It was recently reported that triclocarban was absorbed significantly from soap used during showering in human subjects and that its C(max) in their whole blood ranged from 23 nM to 530 nM. We revealed that a nanomolar concentration (300 nM) of triclocarban potentiated the cytotoxicity of 300 µM H(2)O(2) in rat thymocytes by using cytometric techniques with appropriate fluorescent probes. Although 300 nM triclocarban did not itself increase the population of dead cells (cell lethality), it… 
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