Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance.

@article{Shapira2011NanomedicineFT,
  title={Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance.},
  author={Alina Shapira and Yoav D Livney and Henk J. Broxterman and Yehuda G Assaraf},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2011},
  volume={14 3},
  pages={150-63}
}
Anticancer drug resistance almost invariably emerges and poses major obstacles towards curative therapy of various human malignancies. In the current review we will distinguish between mechanisms of chemoresistance that are predominantly mediated by ATP-driven multidrug resistance (MDR) efflux transporters, typically of the ATP-binding cassette (ABC) superfamily, and those that are independent of such drug efflux pumps. In recent years, multiple nanoparticle (NP)-based therapeutic systems have… CONTINUE READING