Nanomedicine: current status and future prospects

  title={Nanomedicine: current status and future prospects},
  author={S. Moein Moghimi and Alan Christy Hunter and J. C. Murray},
  journal={The FASEB Journal},
  pages={311 - 330}
Applications of nanotechnology for treatment, diagnosis, monitoring, and control of biological systems has recently been referred to as “nanomedicine” by the National Institutes of Health. Research into the rational delivery and targeting of pharmaceutical, therapeutic, and diagnostic agents is at the forefront of projects in nanomedicine. These involve the identification of precise targets (cells and receptors) related to specific clinical conditions and choice of the appropriate nanocarriers… 
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Current advances in nanomedicine raise exciting possibilities for future nanoparticle applications in personalized cancer therapy, and diagnostic agents and chemotherapeutic drugs can be integrated into their design for more efficient imaging and treatment of the tumor with fewer side effects.
Nanomedicines for Cancer Therapy: An Update of FDA Approved and Those under Various Stages of Development
This review provides an update on the FDA approved cancer nanomedicines such as Abraxane, Doxil, daunoxome, Oncaspar, DepoCyt and those in nanoplatforms that have reached an advanced stage of clinical development utilizing liposomes, lipid nanoparticles, lipoplexes, albumin nanospheres, thermosensitive devices, micelles and gold nanoparticles.
Multifunctional nanomedicines: potentials and prospects
This review considers current standing and possible future directions in the emerging area of multifunctional nanocarriers with primary attention on the combination of such properties as longevity, targetability, intracellular penetration, and contrast loading.
Impact of nanoscience and nanotechnology on controlled drug delivery.
For nanomedicines intended to aid CDD in evolving successfully from laboratories to clinics and compete globally and with perhaps an unlimited lifetime, they should also have proven safety, efficacy, acceptability and availability, which indicate that well-planned interdisciplinary approaches will be required.
Nanomedicines for Cancer Therapy : An Update of FDA Approved and Those under Various Stages of Development
Nanomaterials, with their size range that corresponds to basic biological materials such as DNA, vastly increased surface area and unique mechanical, electronic, photonic and magnetic properties are projected to have a wide range of applications from drug and gene delivery to biomedical imaging.
New challenges in the use of nanomedicine in cancer therapy
Nanomedicines are applied as alternative treatments for anticancer agents, increasing their bioavailability and conferring fewer toxic side effects, and nanotechnology is effectively applied in the preparation of such drugs as they are in nm sizes.
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Nanomedicine for respiratory diseases.
Surface-Engineered Cancer Nanomedicine: Rational Design And Recent Progress.
The physicochemical manipulation of cancer nanomedicine for rational design and recent progress in the area of surface engineering ofnanomedicines to improve the efficacy of cancer chemotherapeutics in MDR cancer as well are discussed.


Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor
These results demonstrate the ability to design and produce polymer-based nanodevices for the intracellular targeting of drugs, imaging agents, and other materials.
Nanotech approaches to drug delivery and imaging.
Long-circulating and target-specific nanoparticles: theory to practice.
The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Nanocrystal targeting in vivo
Qdots are small (<10 nm) inorganic nanocrystals that possess unique luminescent properties; their fluorescence emission is stable and tuned by varying the particle size or composition, and these results encourage the construction of more complex nanostructures with capabilities such as disease sensing and drug delivery.
Probing the structural and molecular diversity of tumor vasculature.
Moving smaller in drug discovery and delivery
The emerging micro- and nanotechnology tools, techniques and devices that are being applied to advance the fields of drug discovery and drug delivery are highlighted.
Microparticles and nanoparticles as delivery systems for DNA vaccines.
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  • Biology
    Critical reviews in therapeutic drug carrier systems
  • 2003
The application of microparticles and nanoparticles as DNA vaccine delivery systems will be critically reviewed with a primary focus on those systems that have generated in vivo immune responses.
In vivo cancer targeting and imaging with semiconductor quantum dots
Sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions are achieved and a whole-body macro-illumination system with wavelength-resolved spectral imaging is integrated for efficient background removal and precise delineation of weak spectral signatures.
Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.
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    Journal of controlled release : official journal of the Controlled Release Society
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