Nanomechanics of native thick filaments from indirect flight muscles.

  title={Nanomechanics of native thick filaments from indirect flight muscles.},
  author={Laurent Kreplak and Lori R. Nyland and John L Contompasis and Jim O. Vigoreaux},
  journal={Journal of molecular biology},
  volume={386 5},
During flight, the wings of Drosophila melanogaster beat nearly 200 times per second. The indirect flight muscle fibers that power this movement have evolved to resist the repetitive mechanical stress that results from the 5-ms wing beat cycle at a strain amplitude of 3.5%. In order to understand how this is achieved at the sarcomere level, we have analyzed the mechanical properties of native thick filaments isolated from indirect flight muscle. Single filaments adsorbed onto a solid support… CONTINUE READING