Nanomaterial standards for efficacy and toxicity assessment.

  title={Nanomaterial standards for efficacy and toxicity assessment.},
  author={Pavan P. Adiseshaiah and Jennifer B Hall and Scott E. McNeil},
  journal={Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology},
  volume={2 1},
Decreased toxicity via selective delivery of cancer therapeutics to tumors has become a hallmark achievement of nanotechnology. In order to be optimally efficacious, a systemically administered nanomedicine must reach cancer cells in sufficient quantities to elicit a response and assume its active form within the tumor microenvironment (e.g., be taken up by cancer cells and release a toxic component once within the cytosol or nuclei). Most nanomedicines achieve selective tumor accumulation via… CONTINUE READING