Nanomagnetic actuation of receptor-mediated signal transduction.

Abstract

Complex cell behaviours are triggered by chemical ligands that bind to membrane receptors and alter intracellular signal transduction. However, future biosensors, medical devices and other microtechnologies that incorporate living cells as system components will require actuation mechanisms that are much more rapid, robust, non-invasive and easily integrated with solid-state interfaces. Here we describe a magnetic nanotechnology that activates a biochemical signalling mechanism normally switched on by binding of multivalent chemical ligands. Superparamagnetic 30-nm beads, coated with monovalent ligands and bound to transmembrane receptors, magnetize when exposed to magnetic fields, and aggregate owing to bead-bead attraction in the plane of the membrane. Associated clustering of the bound receptors acts as a nanomagnetic cellular switch that directly transduces magnetic inputs into physiological cellular outputs, with rapid system responsiveness and non-invasive dynamic control. This technique may represent a new actuator mechanism for cell-based microtechnologies and man-machine interfaces.

DOI: 10.1038/nnano.2007.418

Extracted Key Phrases

4 Figures and Tables

Showing 1-10 of 24 references

Electromagnetic needles with submicron pole tip radii for nanomanipulation of biomolecules and living cells

  • B D Matthews, D A Lavan, D R Overby, J Karavitis, D E Ingber
  • 2004

Functional glass slides for in vitro evaluation of interactions between osteosarcoma TE85 cells and mineral-binding ligands

  • J Song, J Chen, C M Klapperich, V Eng, C R Bertozzi
  • 2004
Showing 1-10 of 40 extracted citations
01002002008200920102011201220132014201520162017
Citations per Year

452 Citations

Semantic Scholar estimates that this publication has received between 183 and 920 citations based on the available data.

See our FAQ for additional information.