Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer

@inproceedings{Nourbakhsh2015NanolipoparticlesmediatedMS,
  title={Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer},
  author={Mahnaz Nourbakhsh and Mahmoud Reza Jaafari and Hermann Lage and Khalil Abnous and F. Mosaffa and A Badiee and Javad Behravan},
  booktitle={Iranian journal of basic medical sciences},
  year={2015}
}
OBJECTIVES P-glycoprotein (P-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. Although siRNA delivery to reverse P-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of siRNA requires effective carriers that can deliver siRNA intracellularly with minimal toxicity on target cells. We investigated a special class of PEGylated lipid-based nanoparticles (NP), named… CONTINUE READING

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Nanolipoparticles-mediated MDR1 siRNA delivery: preparation, characterization and cellular uptake

  • M Nourbakhsh, J Behravan, H Lage, K Abnous, F Mosaffa, A Badiee
  • Nanomed J 2015;2:39-45
  • 2015
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