Nanohydroxyapatite-coated electrospun poly(l-lactide) nanofibers enhance osteogenic differentiation of stem cells and induce ectopic bone formation.

@article{Seyedjafari2010NanohydroxyapatitecoatedEP,
  title={Nanohydroxyapatite-coated electrospun poly(l-lactide) nanofibers enhance osteogenic differentiation of stem cells and induce ectopic bone formation.},
  author={Ehsan Seyedjafari and Masoud Soleimani and Nasser Ghaemi and Iman Shabani},
  journal={Biomacromolecules},
  year={2010},
  volume={11 11},
  pages={
          3118-25
        }
}
A combination of calcium phosphates with nanofibrous scaffolds holds promising potential for bone tissue engineering applications. In this study, nanohydroxyapatite (n-HA) was coated on the plasma-treated surface of electrospun poly(l-lactide) (PLLA) nanofibers and the capacity of fabricated scaffolds for bone formation was investigated in vitro using human cord blood derived unrestricted somatic stem cells (USSC) under osteogenic induction and in vivo after subcutaneous implantation. PLLA and… CONTINUE READING

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