Nanogap capacitors : Sensitivity to sample permittivity changes

  title={Nanogap capacitors : Sensitivity to sample permittivity changes},
  author={Cristian Ionescu-Zanetti and J. Tanner Nevill and Dino Di Carlo and Ki‐Hun Jeong and Luke P. Lee},
  journal={Journal of Applied Physics},
In this article, detailed models for a number of nanogap capacitor geometries are presented, and their agreement with impedance spectroscopy data is evaluated. The detection limit is investigated using a technique for the modification of inter-electrode permittivity. Precise changes in permittivity of the sample region are introduced by timed etching of the capacitor spacer and measured in order to determine the system’s sensitivity to changes in sample permittivity. We have focused on a… 

Figures from this paper

Analytical Modeling of Sensitivity Parameters Influenced by Practically Feasible Arrangement of Bio-Molecules in Dielectric Modulated FET Biosensor

In this paper, analytical modeling of a Dielectric Modulated Double Gate Field Effect Transistor (DM-DGFET) for biosensing application is presented with extensive data analysis. Firstly, the size of

A dielectric-modulated field-effect transistor for biosensing.

It is shown here that a FET biosensor with a vertical gap is sensitive to the specific binding of streptavidin to biotin, and believes that the dielectric-modulated FET (DMFET) provides a useful approach towards biomolecular detection that could be extended to a number of other systems.

High-Frequency Nanocapacitor Arrays: Concept, Recent Developments, and Outlook.

This work has developed a measurement platform for performing high-frequency AC detection at nanoelectrodes and shows here that sensitivity down to the attofarad level combined with the small electrode size permits detection of individual 28 nm diameter particles as they land on the sensor surface.

Transport phenomena in nanofluidics

This thesis explores transport phenomena in nanochannels on a chip. Fundamental nanofluidic ionic studies form the basis for novel separation and preconcentration applications for proteomic purposes.

Encyclopedia of Nanotechnology

Nanogap biosensors are made using various microand nano-fabrication techniques to create a nanometer-scale detection region. This region is interrogated using electrical techniques to sense and

Fabrication of a Horizontal and a Vertical Large Surface Area Nanogap Electrochemical Sensor

The detection of peptide nucleic acid (PNA)−DNA binding events is explored using dielectric spectroscopy with the horizontal coplanar device for accurate direct detection of biomolecules through impedimetric or amperometric signals.

Development OF Nanogap Automated Permittivity Measurement System for DNA hybridization detection kit

The Nanogap Automated Permittivity Measurement System (APMS) are fabricated as low cost, portable and label free DNA hybridization detection kit. The nanogap capacitor can react as a dna sensor. The

Analytical modeling and sensitivity analysis of dielectric-modulated junctionless gate stack surrounding gate MOSFET (JLGSSRG) for application as biosensor

An analytical model of dielectric-modulated junctionless gate-stack surrounding gate MOSFET for application as a biosensor is presented. An expression for the channel-center potential is obtained by

Analytical model for a dielectric modulated double gate FET (DM-DG-FET) biosensor

This work presents an analytical model for a dielectric modulated (DM) double gate (DG) MOSFET working as a biosensor. The sensitivity is quantified in terms of relative change in the threshold



A simple fabrication method of nanogap electrodes for top-contacted geometry: application to porphyrin nanorods and a DNA network

We have developed a fabrication method for nanogap electrodes without employing photo- or electron-beam lithography to measure the electrical characteristics of nanostructured molecules. This

Probing Biomolecular Interactions at Conductive and Semiconductive Surfaces by Impedance Spectroscopy: Routes to Impedimetric Immunosensors, DNA‐Sensors, and Enzyme Biosensors

Different immunosensors that use impedance measurements for the transduction of antigen-antibody complex formation on electronic transducers were developed and enzymebased biosensors using impedance measurements as readout signals were developed.

Dielectric relaxation spectroscopy and some applications in the pharmaceutical sciences.

The basis of dielectric theory and the principles of measuring dielectrics properties are detailed, including a comprehensive account of measurement artifacts, and some applications of DRS to the pharmaceutical sciences are given.

Direct current electrical characterization of ds-DNA in nanogap junctions

Evidence is shown that the dc resistance of dry DNA strands of the same length decreases with increasing guanine-cytosine content in the sequence, which can have important consequences in DNA-based molecular electronics and direct label-free detection of DNA hybridization.

Dielectric spectroscopy as a probe for the investigation of conformational properties of proteins.

Differential impedance spectroscopy for monitoring protein immobilization and antibody-antigen reactions.

The theoretical and practical means for elucidating the surface reactivity of biomolecular reagents using ion displacement model with antibody-antigen (Ab-Ag) reaction as the test case are presented.

Etch rates for micromachining processing-Part II

Samples of 53 materials that are used or potentially can be used or in the fabrication of microelectromechanical systems and integrated circuits were prepared: single-crystal silicon with two doping

Photoswitchable Antigen−Antibody Interactions Studied by Impedance Spectroscopy

The photoisomerization of the monolayer interface and the binding or dissociation of DNP-Ab to and from the photoisomersizable monolayers are studied by impedance spectroscopy, in the presence or absence of a solubilized redox probe.

What Can Really Be Learned from Dielectric Spectroscopy of Protein Solutions? A Case Study of Ribonuclease A

We report on a dielectric relaxation study of aqueous solutions of ribonuclease A at 298.15 K as a function of protein concentration between 0.5 and 6 wt % in the MHz/GHz frequency range. The spectra