Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.

@article{Zhou2013NanogSC,
  title={Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.},
  author={Yizhuo Zhou and Shanshan Li and Qiongping Huang and Lele Xie and Xueliang Zhu},
  journal={Journal of molecular cell biology},
  year={2013},
  volume={5 4},
  pages={
          239-49
        }
}
Nanog, Sox2, and Oct4 are key transcription factors critical for the pluripotency and self-renewal of embryonic stem (ES) cells. Their downregulations lead to differentiation, accompanied with changes in cell motility. Whether these factors impact cell motility directly, however, is not clear. Here we addressed this question by initially assessing their effect in non-stem cells. We found that the ectopic expression of Nanog, Sox2, or Oct4 markedly inhibited ECV304 cell migration. Detailed… CONTINUE READING
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