Nanog-Independent Reprogramming to iPSCs with Canonical Factors

@inproceedings{Carter2014NanogIndependentRT,
  title={Nanog-Independent Reprogramming to iPSCs with Canonical Factors},
  author={A. Christopher Guilford Carter and Brandi Davis-Dusenbery and Kathryn Koszka and Justin K Ichida and Kevin C Eggan},
  booktitle={Stem cell reports},
  year={2014}
}
It has been suggested that the transcription factor Nanog is essential for the establishment of pluripotency during the derivation of embryonic stem cells and induced pluripotent stem cells (iPSCs). However, successful reprogramming to pluripotency with a growing list of divergent transcription factors, at ever-increasing efficiencies, suggests that there may be many distinct routes to a pluripotent state. Here, we have investigated whether Nanog is necessary for reprogramming murine… CONTINUE READING
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