Nanog A New Recruit to the Embryonic Stem Cell Orchestra

@article{Cavaleri2003NanogAN,
  title={Nanog A New Recruit to the Embryonic Stem Cell Orchestra},
  author={F. Cavaleri and H. Sch{\"o}ler},
  journal={Cell},
  year={2003},
  volume={113},
  pages={551-552}
}
In this issue of Cell, and add a new transcriptional operating system to the known Oct4 and Stat3 systems required for early embryonal stem cell potency and self-renewal. Nanog, a homeobox transcription factor, plays a crucial role in the second embryonic cell fate specification following formation of the blastocyst. 
[Two vital transcriptional factors Oct-4 and Nanog to keep the pluripotency and self-renewal of stem cells and related regulation network].
Oct-4 and Nanog are two critical transcriptional factors to keep pluripotency and self-renewal of stem cells in vivo and in vitro, and they usually express only in pluripotent cells and not inExpand
Chipping away at 'stemness'
Global gene-expression analyses of human embryonic stem cells confirm the involvement of some known genes in stem-cell function and identify some new candidate regulators of stem-cell growth. SupportExpand
Activated 5′flanking region of NANOGP8 in a self‐renewal environment is associated with increased sphere formation and tumor growth of prostate cancer cells
TLDR
The role of NANOGP8 in cell proliferation has not been completely understood because of the lack of investigation into the regulation of its expression. Expand
Expression and Function of Pluripotency Genes in Adult Stem Cells
TLDR
This chapter discusses whether adult somatic stem cells express the Oct4 and Nanog genes that are known to play a role in the self-renewal and pluripotency characteristics of ESC, and whether such expression plays arole in the potency of adult tissue derived stem cells. Expand
Molecular mechanisms on embryonic stem cell pluripotency
Derived from early embryo, embryonic stem (ES) cells have potential to self renew indefinitely and develop to any type of cells in human body (pluripotency). Several extrinsic signals such as LIF,Expand
SOX2 gene – master regulator of numerous cellular processes
TLDR
The effects ofSOX2 overexpression is studied and some of the recent findings that have highlighted the important roles of SOX2 in the maintenance of pluripotency, proliferation, neural differentiation and in the regulation of the migration capacity of cells are presented. Expand
The Stem Cell Pluripotency Factor NANOG Activates Transcription with Two Unusually Potent Subdomains at Its C Terminus*
  • G. Pan, D. Pei
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2005
TLDR
The evidence that NANOG behaves as a transcription activator with two unusually strong activation domains embedded in its C terminus is provided, suggesting that either WR or CD2 is sufficient for NANog to function as a transactivator. Expand
NaNog: A pluripotency homeobox (master) molecule
TLDR
NaNog, the subject of this article, is a molecule implicated in regulating pluripotency that is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Expand
DjPum, a homologue of Drosophila Pumilio, is essential to planarian stem cell maintenance
TLDR
Through RNA interference (RNAi), it is demonstrated that gene silencing of DjPum dramatically reduces the number of neoblasts, thus supporting the intriguing hypothesis that stem cell maintenance may be an ancestral function of PUF proteins. Expand
Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog
TLDR
It is demonstrated that both regions N- and C- terminal to the homeodomain have transcription activities, and this unique arrangement of dual transactivators may confer nanog the flexibility and specificity to regulate downstream genes critical for both pluripotency and differentiation of stem cells. Expand
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