Nanofibrous gelatine scaffolds integrated with nerve growth factor‐loaded alginate microspheres for brain tissue engineering

  title={Nanofibrous gelatine scaffolds integrated with nerve growth factor‐loaded alginate microspheres for brain tissue engineering},
  author={Melda B{\"u}y{\"u}k{\"o}z and E. Erdal and Sacide Alsoy Altinkaya},
  journal={Journal of Tissue Engineering and Regenerative Medicine},
  pages={e707 - e719}
  • Melda Büyüköz, E. Erdal, Sacide Alsoy Altinkaya
  • Published 2018
  • Chemistry, Medicine
  • Journal of Tissue Engineering and Regenerative Medicine
  • Neural regeneration research is designed in part to develop strategies for therapy after nerve damage due to injury or disease. In this study, a new gelatine‐based biomimetic scaffold was fabricated for brain tissue engineering applications. A technique combining thermally induced phase separation and porogen leaching was used to create interconnected macropores and nanofibrous structure. To promote tissue regeneration processes, the scaffolds were integrated with nerve growth factor (NGF… CONTINUE READING
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    • International journal of biological macromolecules
    • 2020
    • 6
    Current and novel polymeric biomaterials for neural tissue engineering
    • 47
    New forms of electrospun nanofiber materials for biomedical applications.
    • 9


    Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB.
    • 190
    The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres.
    • 250
    Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds.
    • X. Liu, P. Ma
    • Materials Science, Medicine
    • Biomaterials
    • 2009
    • 308
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    Nanostructured Biomaterials for Regeneration.
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    • Materials Science, Medicine
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    • 532
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    Hyaluronic acid hydrogels with IKVAV peptides for tissue repair and axonal regeneration in an injured rat brain.
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    • F. Gu, B. Amsden, R. Neufeld
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    • 2004
    • 210