Nanofibrous gelatine scaffolds integrated with nerve growth factor‐loaded alginate microspheres for brain tissue engineering
@article{Bykz2018NanofibrousGS, title={Nanofibrous gelatine scaffolds integrated with nerve growth factor‐loaded alginate microspheres for brain tissue engineering}, author={Melda B{\"u}y{\"u}k{\"o}z and Esra Erdal and Sacide Alsoy Altinkaya}, journal={Journal of Tissue Engineering and Regenerative Medicine}, year={2018}, volume={12}, pages={e707 - e719} }
Neural regeneration research is designed in part to develop strategies for therapy after nerve damage due to injury or disease. In this study, a new gelatine‐based biomimetic scaffold was fabricated for brain tissue engineering applications. A technique combining thermally induced phase separation and porogen leaching was used to create interconnected macropores and nanofibrous structure. To promote tissue regeneration processes, the scaffolds were integrated with nerve growth factor (NGF…
21 Citations
Fabrication and characterization of chitosan-based composite scaffolds for neural tissue engineering
- Biology, Materials ScienceInternational Journal of Polymeric Materials and Polymeric Biomaterials
- 2021
The results indicated that all these Cs-based composite scaffolds had good biocompatibility without cytotoxicity, while Cs/PEG scaffolds possessed higher cell survival rate and could promote the adhesion, proliferation, and differentiation of PC12 cells.
Regeneration of the Peripheral Nerve via Multifunctional Electrospun Scaffolds.
- Materials ScienceJournal of biomedical materials research. Part A
- 2020
In this systematic review paper, the fabrication methods for the preparation of aligned nanofibrous scaffolds in yarn or conduit architecture are reviewed, and the utilized polymeric materials, including natural, synthetic and blend are presented.
Prospects of Natural Polymeric Scaffolds in Peripheral Nerve Tissue-Regeneration.
- Biology, MedicineAdvances in experimental medicine and biology
- 2018
The present chapter summarizes the advances of the various types of natural polymeric scaffolds such as fibrous scaffolding, porous scaffolds, and hydrogels in nerve-regeneration and repair process and concludes with the present challenges and prospects of efficient exploration of naturalpolymeric scaffold exploration in the future to overcome the problems of nerve- Regeneration associated with various nerve injuries and neurodegenerative disorders.
Synthesis and characterization of alginate and sterculia gum based hydrogel for brain drug delivery applications.
- Biology, EngineeringInternational journal of biological macromolecules
- 2020
3D scaffolds for brain tissue regeneration: architectural challenges.
- Biology, Materials ScienceBiomaterials science
- 2018
This review provides a critical analysis of current 3D scaffolds for neural tissue engineering and evaluated success and shortcomings of various 3D structures through the analysis of tissue integration of the3D scaffold in vivo.
Current and novel polymeric biomaterials for neural tissue engineering
- Biology, Materials ScienceJournal of Biomedical Science
- 2018
Most of neural tissue engineering applications are in pre-clinical study, in particular for use in the central nervous system, however collagen polymer conduits aimed at regeneration of peripheral nerves have already been successfully tested in clinical trials.
Applications of Alginate microspheres in therapeutics delivery and cell culture: past, present and future.
- BiologyInternational journal of pharmaceutics
- 2019
Advancing Regenerative Medicine Through the Development of Scaffold, Cell Biology, Biomaterials and Strategies of Smart Material
- Biology, Materials ScienceRegenerative Engineering and Translational Medicine
- 2021
The fundamentals of regenerative medicine and their development in regeneration of cells and tissues are described as well as the current use of biomaterials in tissue engineering application and its direction in future research are discussed.
New forms of electrospun nanofiber materials for biomedical applications.
- Biology, Materials ScienceJournal of materials chemistry. B
- 2020
This short review discusses the preparation and potential biomedical applications of new forms of nanofiber materials including expanded nan ofiber scaffolds, nanof fiber aerogels, short nanofibers, andnanofiber microspheres.
Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications
- Biology, Materials SciencePharmaceutics
- 2021
This work reviews strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications.
References
SHOWING 1-10 OF 44 REFERENCES
Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB.
- Biology, Materials ScienceJournal of controlled release : official journal of the Controlled Release Society
- 2006
The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres.
- Biology, Materials ScienceBiomaterials
- 2007
Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds.
- Materials Science, BiologyBiomaterials
- 2009
Nanostructured Biomaterials for Regeneration
- Biology, Materials ScienceAdvanced functional materials
- 2008
Nano-scaled drug delivery systems can be successfully incorporated into a porous 3D scaffold to enhance the tissue regeneration capacity and nano-structured biomateials are providing new enabling technologies for regenerative medicine.
Biodegradable polymer scaffolds with well-defined interconnected spherical pore network.
- Materials Science, BiologyTissue engineering
- 2001
A novel processing technique has been developed to create three-dimensional biodegradable polymer scaffolds with well-controlled interconnected spherical pores that can tailor the polymer scaffold for a variety of potential tissue engineering applications because of the well- controlled architecture, interpore connectivity, and mechanical properties.
The use of poly(l-lactide) and RGD modified microspheres as cell carriers in a flow intermittency bioreactor for tissue engineering cartilage.
- Biology, Materials ScienceBiomaterials
- 2006
Hyaluronic acid hydrogels with IKVAV peptides for tissue repair and axonal regeneration in an injured rat brain.
- Biology, Materials ScienceBiomedical materials
- 2007
A biocompatible hydrogel of hyaluronic acid with the neurite-promoting peptide sequence of IKVAV has the potential to repair tissue defects in the central nervous system by promoting the formation of a tissue matrix and axonal growth by replacing the lost tissue.
Sustained delivery of vascular endothelial growth factor with alginate beads.
- BiologyJournal of controlled release : official journal of the Controlled Release Society
- 2004
Accelerating proliferation of neural stem/progenitor cells in collagen sponges immobilized with engineered basic fibroblast growth factor for nervous system tissue engineering.
- Biology, EngineeringBiomacromolecules
- 2014
A natural biological neural scaffold consisting of collagen sponges, engineered bFGF, and NS/PCs is designed, which could have a direct effect on nervous system reconstruction.
The treatment of TBI with human marrow stromal cells impregnated into collagen scaffold: Functional outcome and gene expression profile
- Biology, MedicineBrain Research
- 2011