Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site.

@article{Li2009NanofiberSW,
  title={Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site.},
  author={Xiaoran Li and Jingwei Xie and Justin Herrold Lipner and Xiaoyan Yuan and Stavros Thomopoulos and Younan Xia},
  journal={Nano letters},
  year={2009},
  volume={9 7},
  pages={2763-8}
}
We have demonstrated a simple and versatile method for generating a continuously graded, bonelike calcium phosphate coating on a nonwoven mat of electrospun nanofibers. A linear gradient in calcium phosphate content could be achieved across the surface of the nanofiber mat. The gradient had functional consequences with regard to stiffness and biological activity. Specifically, the gradient in mineral content resulted in a gradient in the stiffness of the scaffold and further influenced the… CONTINUE READING