Nanoemulsions loaded with amphotericin B: a new approach for the treatment of leishmaniasis.

Abstract

This work aimed to develop nanoemulsions (NE) containing cholesterol and Amphotericin B (AmB) evaluating the influence of a lipophilic amine (stearylamine; STE) on drug encapsulation efficiency (EE), cytotoxicity on macrophages and in vitro antileishmanial activity. The EE of AmB in NE was nearly 100% regardless of STE concentration. Stability studies… (More)
DOI: 10.1016/j.ejps.2015.01.015

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