Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice.

@article{Ragelle2012NanoemulsionFO,
  title={Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice.},
  author={H{\'e}lo{\"i}se Ragelle and Sylvie Crauste-Manciet and Johanne Seguin and Denis Brossard and Daniel Scherman and Philippe Arnaud and Guy G. Chabot},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={427 2},
  pages={452-9}
}
The natural flavonoid fisetin (3,3',4',7-tetrahydroxyflavone) has shown antitumour activity but its administration is complicated by its low water solubility. Our aim was to incorporate fisetin into a nanoemulsion to improve its pharmacokinetics and therapeutic efficacy. Solubility and emulsification tests allowed to develop an optimal nanoemulsion composed of Miglyol 812N/Labrasol/Tween 80/Lipoid E80/water (10%/10%/2.5%/1.2%/76.3%). The nanoemulsion had an oil droplet diameter of 153 ± 2 nm, a… CONTINUE READING

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