Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.

  title={Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.},
  author={Edward Kai-Hua Chow and Xue-Qing Zhang and Mark Chen and Robert G. Lam and Erik Robinson and Houjin Huang and Daniel Schaffer and Eiji Osawa and Andrei Goga and Dean Ho},
  journal={Science translational medicine},
  volume={3 73},
Enhancing chemotherapeutic efficiency through improved drug delivery would facilitate treatment of chemoresistant cancers, such as recurrent mammary tumors and liver cancer. One way to improve drug delivery is through the use of nanodiamond (ND) therapies, which are both scalable and biocompatible. Here, we examined the efficacy of an ND-conjugated chemotherapeutic in mouse models of liver and mammary cancer. A complex (NDX) of ND and doxorubicin (Dox) overcame drug efflux and significantly… CONTINUE READING
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