Nanocytotoxicity: violacein and violacein-loaded poly (D, L-lactide-co-glycolide) nanoparticles acting on human leukemic cells.

@article{Melo2009NanocytotoxicityVA,
  title={Nanocytotoxicity: violacein and violacein-loaded poly (D, L-lactide-co-glycolide) nanoparticles acting on human leukemic cells.},
  author={Patr{\'i}cia da Silva Melo and Marcelo M M de Azevedo and Lucas Frungillo and Maristela Conti Anazetti and Priscyla Daniely Marcato and Nelson Dur{\'a}n},
  journal={Journal of biomedical nanotechnology},
  year={2009},
  volume={5 2},
  pages={192-201}
}
Violacein is a compound obtained from Chromobacterium violaceum, a bacterium found in the Amazonian region. Violacein-loaded poly (D, L-lactide-co-glycolide) nanoparticles has a similar inhibitory effect evaluated by trypan blue assay on leukemic HL60 cells than the free form. However, the cytotoxic effects evaluated by phosphatase activity and MTT reduction assays were lower for the encapsulated form than for free violacein. Based on morphological changes, violacein and violacein entrapped in… CONTINUE READING
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