Nanocrystals of medium soluble actives--novel concept for improved dermal delivery and production strategy.

Abstract

After use in oral pharmaceutical products, nanocrystals are meanwhile applied to improve the dermal penetration of cosmetic actives (e.g. rutin, hesperidin) and of drugs. By now, nanocrystals are only dermally applied made from poorly soluble actives. The novel concept is to formulate nanocrystals also from medium soluble actives, and to apply a dermal… (More)
DOI: 10.1016/j.ijpharm.2014.04.060

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