Nanoconjugate based on polymalic acid for tumor targeting.

  title={Nanoconjugate based on polymalic acid for tumor targeting.},
  author={Julia Y. Ljubimova and Manabu Fujita and Natalya M. Khazenzon and Bong-Seop Lee and Sebastian Wachsmann-Hogiu and Daniel L. Farkas and Keith L. Black and Eggehard Holler},
  journal={Chemico-biological interactions},
  volume={171 2},
A new prototype of polymer-derived drug delivery system, the nanoconjugate Polycefin, was tested for its ability to accumulate in tumors based on enhanced permeability and retention (EPR) effect and receptor mediated endocytosis. Polycefin was synthesized for targeted delivery of Morpholino antisense oligonucleotides into certain tumors. It consists of units that are covalently conjugated with poly(beta-l-malic acid) (M(w) 50,000, M(w)/M(n) 1.3) highly purified from cultures of myxomycete… CONTINUE READING


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