Nanoconjugate based on polymalic acid for tumor targeting.

@article{Ljubimova2008NanoconjugateBO,
  title={Nanoconjugate based on polymalic acid for tumor targeting.},
  author={J. Ljubimova and M. Fujita and N. M. Khazenzon and Bong-Seop Lee and S. Wachsmann-Hogiu and D. Farkas and K. Black and E. Holler},
  journal={Chemico-biological interactions},
  year={2008},
  volume={171 2},
  pages={
          195-203
        }
}
A new prototype of polymer-derived drug delivery system, the nanoconjugate Polycefin, was tested for its ability to accumulate in tumors based on enhanced permeability and retention (EPR) effect and receptor mediated endocytosis. Polycefin was synthesized for targeted delivery of Morpholino antisense oligonucleotides into certain tumors. It consists of units that are covalently conjugated with poly(beta-l-malic acid) (M(w) 50,000, M(w)/M(n) 1.3) highly purified from cultures of myxomycete… Expand
Preparation of poly(β-L-malic acid)-based charge-conversional nanoconjugates for tumor-specific uptake and cellular delivery
Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer.
Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid).
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