Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances.

@article{Gandhi2014NanocarrierMD,
  title={Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances.},
  author={Nishant S. Gandhi and Rakesh Kumar Tekade and Mahavir Bhupal Chougule},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={194},
  pages={238-56}
}
Chemotherapeutic agents have certain limitations when it comes to treating cancer, the most important being severe side effects along with multidrug resistance developed against them. Tumor cells exhibit drug resistance due to activation of various cellular level processes viz. activation of drug efflux pumps, anti-apoptotic defense mechanisms, etc. Currently, RNA interference (RNAi) based therapeutic approaches are under vibrant scrutinization to seek cancer cure. Especially small interfering… CONTINUE READING
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