Nanocarrier improves the bioavailability, stability and antitumor activity of camptothecin.

@article{Tang2014NanocarrierIT,
  title={Nanocarrier improves the bioavailability, stability and antitumor activity of camptothecin.},
  author={Xin-Jiang Tang and Min Han and Bo Yang and Youqing Shen and Zhong-gui He and Dong-hang Xu and Jianqing Gao},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={477 1-2},
  pages={
          536-45
        }
}
Camptothecin (CPT) nanosuspension was prepared by anti-solvent precipitation with TPGS as stabilizer to improve the solubility, stability and antitumor activity of CPT. And an increased solubility, stability and dissolution rate was achieved after nanosuspension being prepared. While, enhanced intracellular accumulation and cellular cytotoxicity was also observed for CPT nanosuspension than that of CPT solution.In addition, nanosuspension could increase bioavailability and intratumor… CONTINUE READING

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