Nanobiocomposite of poly(lactide-co-glycolide)/chitosan electrospun scaffold can promote proliferation and transdifferentiation of Schwann-like cells from human adipose-derived stem cells.

@article{Razavi2015NanobiocompositeOP,
  title={Nanobiocomposite of poly(lactide-co-glycolide)/chitosan electrospun scaffold can promote proliferation and transdifferentiation of Schwann-like cells from human adipose-derived stem cells.},
  author={Shahnaz Razavi Razavi and Hamid Zarkesh-Esfahani and Mohammad Monir Morshed and Sedigheh Vaezifar and Saeed Karbasi and Mohammad Ali Golozar},
  journal={Journal of biomedical materials research. Part A},
  year={2015},
  volume={103 8},
  pages={2628-34}
}
The transdifferentiation of human adipose-derived stem cells (ADSCs) into Schwann-like cells on biocomposite scaffolds may be a critical issue in nerve regeneration medicine. In this study, tissue-engineered scaffold with chitosan (CS) nanopowders and poly(lactide-co-glycolide) (PLGA) was investigated for its potential Schwann cells (SCs) transdifferentiation. The differentiation of human ADSCs into S-like cells was induced with different CS content and direction of nanofibers on PLGA/CS… CONTINUE READING