Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines

@inproceedings{Leneghan2017NanoassemblyRS,
  title={Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines},
  author={Darren B Leneghan and Kazutoyo Miura and Iona J. Taylor and Yuanyuan Li and Jing Jin and Karl D Brune and Martin F Bachmann and Mark Howarth and Carole A. Long and Sumi Biswas},
  booktitle={Scientific Reports},
  year={2017}
}
Vaccine development efforts have recently focused on enabling strong immune responses to poorly immunogenic antigens, via display on multimerisation scaffolds or virus like particles (VLPs). Typically such studies demonstrate improved antibody titer comparing monomeric and nano-arrayed antigen. There are many such studies and scaffold technologies, but minimal side-by-side evaluation of platforms for both the amount and efficacy of antibodies induced. Here we present direct comparison of three… CONTINUE READING
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References

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SHOWING 1-10 OF 67 REFERENCES

MVA 85 A - IMX 313 , administered to BCG - vaccinated adults

J. Feng
  • 2016

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