Nano- to microscale dynamics of P-selectin detachment from leukocyte interfaces. I. Membrane separation from the cytoskeleton.

@article{Evans2005NanoTM,
  title={Nano- to microscale dynamics of P-selectin detachment from leukocyte interfaces. I. Membrane separation from the cytoskeleton.},
  author={Evan A. Evans and Volkmar Heinrich and Andrew Leung and Koji Kinoshita},
  journal={Biophysical journal},
  year={2005},
  volume={88 3},
  pages={2288-98}
}
We have used a biomembrane force probe decorated with P-selectin to form point attachments with PSGL-1 receptors on a human neutrophil (PMN) in a calcium-containing medium and then to quantify the forces experienced by the attachment during retraction of the PMN at fixed speed. From first touch to final detachment, the typical force history exhibited the following sequence of events: i), an initial linear-elastic displacement of the PMN surface, ii), an abrupt crossover to viscoplastic flow… CONTINUE READING
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Static and dynamic lengths of neutrophil microvilli

  • Shao, J.-Y., H. P. Ting-Beall, R. M. Hochmuth.
  • Proc. Natl. Acad. Sci. USA. 95:6797–6802.
  • 1998
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Nano- to microscale dynamics of P-selectin detachment from leukocyte interfaces

  • M. R. King, V. Heinrich, E. Evans, D. A. Hammer.
  • III. Numerical simulation of tethering under flow…
  • 2005

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