Nano-sized carbon black exposure exacerbates atherosclerosis in LDL-receptor knockout mice.

  title={Nano-sized carbon black exposure exacerbates atherosclerosis in LDL-receptor knockout mice.},
  author={Yasuharu Niwa and Yumiko Hiura and Toshinori Murayama and Masayuki Yokode and Naoharu Iwai},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  volume={71 7},
BACKGROUND Associations between exposure to particulate matter and susceptibility to cardiovascular events have been reported. Although the underlying mechanisms are not fully understood, this association seems to be particularly exaggerated in the presence of atherothrombotic risk factors. The present study was undertaken in low-density lipoprotein receptor knockout (LDLR/KO) mice to test the hypothesis that long-term exposure to a high dose of nano-sized carbon black (CB) exacerbates… CONTINUE READING


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