Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes

@article{Zhi2011NanoscaleEE,
  title={Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes},
  author={Z.-l. Zhi and Alan Kerby and Aileen J. F. King and Philip Mills Jones and John C Pickup},
  journal={Diabetologia},
  year={2011},
  volume={55},
  pages={1081-1090}
}
The success of islet transplantation as a treatment for type 1 diabetes is currently hampered by post-transplantation loss of functional islets through adverse immune and non-immune reactions. We aimed to test whether early islet loss can be limited and transplant survival improved by the application of conformal nano-coating layers to islets. Our novel coating protocol used alternate layers of phosphorylcholine-derived polysaccharides (chitosan or chondroitin-4-sulphate) and alginate as… CONTINUE READING
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