Nano partículas contendo o análogo da mexiletina, JME-173desenvolvimento, caracterização e avaliação farmacológica em modelo de inflamação pulmonar induzida por LPS

@inproceedings{Coutinho2017NanoPC,
  title={Nano part{\'i}culas contendo o an{\'a}logo da mexiletina, JME-173desenvolvimento, caracterizaç{\~a}o e avaliaç{\~a}o farmacol{\'o}gica em modelo de inflamaç{\~a}o pulmonar induzida por LPS},
  author={Diego de S{\'a} Coutinho},
  year={2017}
}
Prior studies have suggested that non-anesthetic analogs of lidocaine might be a means of achieving the anti- asthmatic effects of lidocaine without the local anesthetic (LA) effect, which has been associated to adverse effects. JME-173, a non-anesthetic analogue of the LA mexiletine was designed to act as an oral anti-inflammatory and bronchodilator agent. However, although active in experimental asthma when nebulized, its oral effect was very poor. The aim of this study was the development… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 248 REFERENCES

Asthma heterogeneity and severity

  • The World Allergy Organization journal
  • 2016
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Cellular and molecular mechanisms of asthma and COPD

J. Barnes Peter
  • Clinical Science
  • 2016
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL