Nano-dissection and sequencing of DNA at single sub-nuclear structures.

  title={Nano-dissection and sequencing of DNA at single sub-nuclear structures.},
  author={Brandon K. Chen and David R P Anchel and Zheng Gong and Rachel Cotton and Ren Li and Yu Sun and D. P. Bazett-Jones},
  volume={10 16},
The relative positioning of gene loci within a mammalian nucleus is non-random and plays a role in gene regulation. Some sub-nuclear structures may represent "hubs" that bring specific genetic loci into close proximity where co-regulatory mechanisms can operate. The identification of loci in proximity to a shared sub-nuclear structure can provide insights… CONTINUE READING