Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance.

@article{Kadam2012NanoadvantageIE,
  title={Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance.},
  author={Rajendra S. Kadam and David W. A. Bourne and Uday B. Kompella},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 7},
  pages={1380-8}
}
The aim of this study was to investigate the contribution of reduced apparent clearance to the enhanced exposure reported for biodegradable nanoparticles after extravascular and intravascular routes of administration. Plasma concentration profiles for drug and nanoparticle formulations after administration by intravenous, intraduodenal, and oral routes were extracted from the literature. Data were fit to pharmacokinetic models using BOOMER. The compartmental pharmacokinetic analysis of… CONTINUE READING

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