Nano-SAR development for bioactivity of nanoparticles with considerations of decision boundaries.

@article{Liu2013NanoSARDF,
  title={Nano-SAR development for bioactivity of nanoparticles with considerations of decision boundaries.},
  author={Rong Liu and Robert Rallo and Ralph Weissleder and Carlos Tassa and Stanley Y. Shaw and Yoram Cohen},
  journal={Small},
  year={2013},
  volume={9 9-10},
  pages={1842-52}
}
The development of classification nano-structure-activity Relationships (nano-SARs) of nanoparticle (NP) bioactivity is presented with the aim of demonstrating the integration of multiparametric toxicity/bioactivity assays to arrive at statistically meaningful class definitions (i.e., bioactivity/inactivity endpoints), as well as the implications of nano-SAR applicability domains and decision boundaries. Nano-SARs are constructed based on a dataset of 44 iron oxide core nanoparticles (NPs… CONTINUE READING
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