Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.

@article{Mundargi2008NanomicroTF,
  title={Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.},
  author={Raghavendra C Mundargi and Vikram Ramesh Babu and Vidhya Rangaswamy and Pradip P. Patel and Tejraj M. Aminabhavi},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2008},
  volume={125 3},
  pages={193-209}
}
Biodegradable nano/microparticles of poly(D,L-lactide-co-glycolide) (PLGA) and PLGA-based polymers are widely explored as carriers for controlled delivery of macromolecular therapeutics such as proteins, peptides, vaccines, genes, antigens, growth factors, etc. These devices are mainly produced by emulsion or double-emulsion technique followed by solvent evaporation or spray drying. Drug encapsulation, particle size, additives added during formulation, molecular weight, ratio of lactide to… CONTINUE READING
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