Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.

@article{Revollo2007NamptPBEFVisfatinRI,
  title={Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.},
  author={Javier R Revollo and Antje K{\"o}rner and Kathryn F. Mills and Akiko Satoh and Tao Wang and Antje Garten and Biplab Dasgupta and Yo Sasaki and Cynthia Wolberger and Raymond R. Townsend and Jeffrey Milbrandt and Wieland Kiess and Shin-ichiro Imai},
  journal={Cell metabolism},
  year={2007},
  volume={6 5},
  pages={
          363-75
        }
}
Intracellular nicotinamide phosphoribosyltransferase (iNampt) is an essential enzyme in the NAD biosynthetic pathway. An extracellular form of this protein (eNampt) has been reported to act as a cytokine named PBEF or an insulin-mimetic hormone named visfatin, but its physiological relevance remains controversial. Here we show that eNampt does not exert insulin-mimetic effects in vitro or in vivo but rather exhibits robust NAD biosynthetic activity. Haplodeficiency and chemical inhibition of… CONTINUE READING

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