Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation.

@article{Ray2010NaltrexoneSE,
  title={Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation.},
  author={Lara A Ray and Kent Hutchison and James R Ashenhurst and A. Leslie Morrow},
  journal={Alcoholism, clinical and experimental research},
  year={2010},
  volume={34 8},
  pages={
          1479-87
        }
}
BACKGROUND Preclinical studies have implicated GABAergic neurosteroids in behavioral responses to alcohol. Naltrexone is thought to blunt the reinforcing effects of alcohol, and a few studies have found that the effects of naltrexone are moderated by the Asn40Asp polymorphisms of the OPRM1 gene. The present study seeks to integrate these lines of research by testing (i) the moderating role of the functional Asn40Asp polymorphism of the OPRM1 gene on naltrexone-induced alternations in GABAergic… CONTINUE READING

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