Naltrexone modulates body and brain development in rats: a role for endogenous opioid systems in growth.

@article{Zagon1984NaltrexoneMB,
  title={Naltrexone modulates body and brain development in rats: a role for endogenous opioid systems in growth.},
  author={Ian S. Zagon and P J Mclaughlin},
  journal={Life sciences},
  year={1984},
  volume={35 20},
  pages={
          2057-64
        }
}
Preweaning rats receiving daily injections of 20, 50, or 100 mg/kg naltrexone, a potent opiate antagonist, had body and brain weights that were increased 16-22% and 6-13%, respectively, from control levels on day 21 (weaning). All of these dosages of naltrexone blocked the opiate receptor for 24 hr/day as measured in opiate challenge experiments. Dosages of 0.1, 1, and 10 mg/kg naltrexone, which blocked the opiate receptor for less than 12 hr/day, inhibited growth. Repetitive administration of… CONTINUE READING

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