Naltrexone-facilitated buprenorphine discontinuation: a feasibility trial.

  title={Naltrexone-facilitated buprenorphine discontinuation: a feasibility trial.},
  author={Elias Dakwar and Herbert D. Kleber},
  journal={Journal of substance abuse treatment},
RATIONALE Buprenorphine is an effective and popular treatment for opioid dependence. It remains unclear, however, when or how to transition stable buprenorphine-maintained individuals to complete abstinence. This trial investigates the feasibility of using naltrexone to facilitate buprenorphine discontinuation in stable individuals who had tolerated a taper to 2mg or less but were unable to terminate entirely due to withdrawal-related distress. METHODS The sample consisted of 6 buprenorphine… CONTINUE READING
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