Naltrexone does not increase brain and body development in rats.


Two strains of preweanling rats (88 Long-Evans; 120 Sprague-Dawley) were given daily SC injections of either 50 mg/kg naltrexone or the equivalent volume of saline, from birth to postnatal day 21. Brain and body weights were assessed at the end of the injections, and in Long-Evans animals, significant differences were noted on both measures with the outcome favoring the control animals. No significant differences were observed between the naltrexone and control Sprague-Dawley rats. These results disconfirm the hypothesis that increased postnatal growth is accomplished by prolonged early postnatal opioid receptor blockade.

Cite this paper

@article{Petrie1993NaltrexoneDN, title={Naltrexone does not increase brain and body development in rats.}, author={Benjamin Petrie}, journal={Neurotoxicology and teratology}, year={1993}, volume={15 4}, pages={275-7} }