Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: a possible mechanism for the dissociation of primary and secondary reward.

@article{Anggadiredja2004NaltrexoneAC,
  title={Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: a possible mechanism for the dissociation of primary and secondary reward.},
  author={Kusnandar Anggadiredja and Katsuya Sakimura and Takato Hiranita and Tsuneyuki Yamamoto},
  journal={Brain research},
  year={2004},
  volume={1021 2},
  pages={272-6}
}
The present study was aimed to clarify the role of the opioid system in the reinstatement of methamphetamine (METH)-seeking behavior in METH self-administering rats. Following 12 days of self-administration of METH, the replacement of METH with saline resulted in a gradual decrease in lever press responses (extinction). Under extinction conditions, METH-priming or re-exposure to cues previously paired with METH infusion markedly increased the responses (reinstatement of drug-seeking… CONTINUE READING

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