• Medicine
• Published in
  Clinical pharmacology and…
  1976
• DOI:10.1002/cpt1976203315

Naltrexone: disposition, metabolism, and effects after acute and chronic dosing.

@article{Verebey1976NaltrexoneDM,
  title={Naltrexone: disposition, metabolism, and effects after acute and chronic dosing.},
  author={Karl Verebey and Jan Volavka and Salvatore J. Mul{\'e} and Richard B. Resnick},
  journal={Clinical pharmacology and therapeutics},
  year={1976},
  volume={20 3},
  pages={
          315-28
        }
}

• Karl Verebey, Jan Volavka, +1 author Richard B. Resnick

The disposition of naltrexone during acute and chronic administration of 100-mg oral dose was studied in 4 subjects. Following an acute dose the mean (X) peak naltrexone plasma level was 43.6 +/- 29.9 ng/ml at 1 hr and for the major biotransformation product, beta-naltrexol, was 87.2 +/- 25.0 ng/ml at 2 hr. Twenty-four hours after the dose the X levels of naltrexone and beta-naltrexol declined to 2.1 +/- 0.47 and 17.6 +/- 5.0 ng/ml, respectively. Following chronic administration and X peak… CONTINUE READING

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