Naloxone reverses the antihypertensive effect of clonidine.

@article{Farsang1979NaloxoneRT,
  title={Naloxone reverses the antihypertensive effect of clonidine.},
  author={Csaba Farsang and George Kunos},
  journal={British journal of pharmacology},
  year={1979},
  volume={67 2},
  pages={161-4}
}
In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone did not affect either blood pressure or heart rate. In brain membranes from spontaneously hypertensive rats clonidine, 10(-8) to 10(-5) M, did not influence stereoselective binding… CONTINUE READING
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