Naloxone reverses L-dopa induced overstimulation effects in a Parkinson's disease animal model analogue.

@article{Carey1991NaloxoneRL,
  title={Naloxone reverses L-dopa induced overstimulation effects in a Parkinson's disease animal model analogue.},
  author={Robert J. Carey},
  journal={Life sciences},
  year={1991},
  volume={48 13},
  pages={
          1303-8
        }
}
Chronic L-DOPA treatment of Parkinson's disease frequently leads to the development of motoric overstimulation and hyperkinetic movements. To investigate this problem in the laboratory, rats surgically altered by unilateral 6-hydroxydopamine lesions (6-OHDA) were chronically treated with one L-DOPA (10 mg/kg i.p.) injection per day for 20 days. In this 6-OHDA rotation model, the unilateral dopamine denervation results in a profound contralateral sensory-motor neglect and the animals… CONTINUE READING

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