Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans.

@article{Koppert2003NaloxonePS,
  title={Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans.},
  author={Wolfgang Koppert and Martin Angst and Monika Alsheimer and Reinhard Sittl and Sven Albrecht and J{\"u}rgen Sch{\"u}ttler and Martin Schmelz},
  journal={Pain},
  year={2003},
  volume={106 1-2},
  pages={91-9}
}
In contrast to an expected preventive analgesic effect, clinical observations suggest that intraoperatively applied opioids can induce postoperative hyperalgesia. We tested the development of post-infusion hyperalgesia in a newly developed experimental model of electrically induced pain and secondary mechanical hyperalgesia. In a double-blind, placebo controlled, cross-over study, 13 subjects received either saline placebo, remifentanil (0.05 or 0.1 microg/kg/min) or naloxone (0.01 mg/kg… CONTINUE READING

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