Naloxone pro-drug rescues morphine induced respiratory depression in Sprague-Dawley rats.

Abstract

Respiratory depression is the main obstacle for the safe administration of morphine for acute pain after injury. Due to this complication, new delivery methods are needed to insure that safe and effective doses of opioid analgesics are administered during emergencies. A depot formulation containing a naloxone pro-drug was designed to release the antidote… (More)
DOI: 10.1016/j.resp.2011.10.009

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Cite this paper

@article{Wallisch2012NaloxonePR, title={Naloxone pro-drug rescues morphine induced respiratory depression in Sprague-Dawley rats.}, author={Michael Wallisch and Nehad M El Rody and Baohua Huang and Dennis R. Koop and James J. Baker and G Douglas Olsen}, journal={Respiratory physiology & neurobiology}, year={2012}, volume={180 1}, pages={52-60} }