Naloxone precipitates nicotine abstinence syndrome and attenuates nicotine-induced antinociception in mice.

@article{Biaa2005NaloxonePN,
  title={Naloxone precipitates nicotine abstinence syndrome and attenuates nicotine-induced antinociception in mice.},
  author={Grażyna Biała and Barbara Budzynska and Marta Kruk},
  journal={Pharmacological reports : PR},
  year={2005},
  volume={57 6},
  pages={755-60}
}
The present study focused on the evaluation of a role of opioid system in nicotine-induced antinociception and physical dependence in mice. The results indicate that nicotine (3 mg/kg) produced a significant antinociception in the hot plate test. Additionally, the opioid receptor antagonist naloxone (0.5 and 1 mg/kg), dose-dependently attenuated this effect. Our second experimental protocol consisted in intermittent administration of nicotine (2.5 mg/kg, s.c.) four times daily for 7 days. In… CONTINUE READING

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Wêgliñska B: Calcium channel antagonists attenuate cross-sensitization to the rewarding and/or locomotor effects of nicotine, morphine and MK-801

  • G Biala
  • J Pharm Pharmacol,
  • 2004
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