Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: Comparison of different mouse strains

@article{Liu2011NaloxoneprecipitatedMW,
  title={Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: Comparison of different mouse strains},
  author={Liang Liu and Janet K Coller and Linda R Watkins and Andrew A Somogyi and Mark R Hutchinson},
  journal={Brain, Behavior, and Immunity},
  year={2011},
  volume={25},
  pages={1223-1232}
}
The development of opioid dependence involves classical neuronal opioid receptor activation and is due in part to engagement of glia causing a proinflammatory response. Such opioid-induced glial activation occurs, at least in part, through a non-classical opioid mechanism involving Toll-like-receptor 4 (TLR4). Among the immune factors released following the opioid-glia-TLR4 interaction, interleukin-1β (IL-1β) plays a prominent role. Previous animal behavioral studies have demonstrated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Morphine Tolerance and Physical Dependence Are Altered in Conditional HIV-1 Tat Transgenic Mice.

  • The Journal of pharmacology and experimental therapeutics
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Toll-like receptor 2 is required for opioids-induced neuronal apoptosis

Y. Li, H. Li, +6 authors D. Yin
  • Biochem. Biophys. Res
  • 2010
VIEW 1 EXCERPT