Naloxone-induced withdrawal in patients with buprenorphine dependence.

@article{Nigam1994NaloxoneinducedWI,
  title={Naloxone-induced withdrawal in patients with buprenorphine dependence.},
  author={Anil K. Nigam and Rajesh P. Srivastava and Sunita Saxena and Bir Singh Chavan and K. R. Sundaram},
  journal={Addiction},
  year={1994},
  volume={89 3},
  pages={317-20}
}
Naloxone-induced withdrawal was studied in seven patients currently dependent only on injecting buprenorphine, within 3 to 6 hours of their last dose. Withdrawal severity began to rise from 5 minutes and reached a peak at 60 minutes after 1.2 mg naloxone given intravenously. The mean withdrawal severity score was significantly higher at 30, 60 and 90… CONTINUE READING