Naloxone-induced cortisol predicts mu opioid receptor binding potential in specific brain regions of healthy subjects

@article{Wand2011NaloxoneinducedCP,
  title={Naloxone-induced cortisol predicts mu opioid receptor binding potential in specific brain regions of healthy subjects},
  author={Gary Wand and Elise M Weerts and Hiroto Kuwabara and James Frost and Mary E McCaul},
  journal={Psychoneuroendocrinology},
  year={2011},
  volume={36},
  pages={1453-1459}
}
Investigators have administered the opioid receptor antagonist, naloxone, to interrogate the hypothalamic-pituitary-adrenal (HPA) axis response under the assumption that this technique provides a measure of endogenous opioid activity. However it has never been tested whether provocation of the HPA axis with naloxone provides a surrogate marker for direct measurement of endogenous opioid activity using PET imaging as the gold standard. To test this hypothesis, eighteen healthy subjects underwent… CONTINUE READING

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