Naloxone decreases tolerance to hypotensive, hypovolemic stress healthy humans.


OBJECTIVE In animal studies, naloxone, an opioid receptor antagonist, improves tolerance to hemorrhagic shock. The purpose of this study was to determine whether naloxone would augment tolerance to hypotensive hypovolemic stress (lower body negative pressure [LBNP]) in healthy human males. DESIGN This study was a repeated measures design. SETTING The… (More)