Naloxone attenuates the conditioned place preference induced by wheel running in rats

@article{Lett2001NaloxoneAT,
  title={Naloxone attenuates the conditioned place preference induced by wheel running in rats},
  author={Bow Tong Lett and Virginia L. Grant and Ming Teng Koh},
  journal={Physiology & Behavior},
  year={2001},
  volume={72},
  pages={355-358}
}
Pairings, during which an episode of wheel running is followed by confinement in a distinctive place, produce conditioned place preference (CPP) in rats. This finding indicates that wheel running has a rewarding effect that outlasts the activity itself. In two similar experiments, we tested the hypothesis that this rewarding effect of wheel running is mediated by endogenous opioids. During a paired trial, the rats in the naloxone group were first allowed to wheel run for 2 h, then injected with… CONTINUE READING

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